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Cheesy Meatloaf Casserole

Stephanie
April 25, 2026
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Cheesy Meatloaf Casserole baked dish with melted cheese

Cheesy Meatloaf Casserole is a comforting dish that brings together the classic flavors of meatloaf in a convenient casserole format. It’s hearty, cheesy, and perfect for busy weeknights. With simple ingredients and a few easy steps, you’ll have a delicious meal the whole family will love!

Why You’ll Love This Cheesy Meatloaf Casserole

  • Packed with flavor from the juicy ground beef and melted cheese.
  • Quick to prepare, making it ideal for busy families.
  • Great for meal prep; leftovers make for tasty lunches.
  • Kid-friendly and sure to please even the pickiest eaters.
  • One-dish meal that minimizes cleanup.

Cheesy Meatloaf Casserole

Ingredients Needed

  • Protein

    • 1 lb ground beef
  • Rice/Grains

    • 1 cup breadcrumbs
  • Veggies

    • 1 onion, chopped
  • Cheese

    • 1 cup shredded cheese
  • Liquid

    • 1/2 cup milk
  • Binders

    • 1 egg
  • Sauce

    • 1/2 cup ketchup
  • Spices

    • 1 tsp garlic powder
    • Salt and pepper to taste

Cheesy Meatloaf Casserole

Step-by-Step Instructions

Step 1:

Preheat the oven to 350°F (175°C).

Step 2:

In a large bowl, combine ground beef, breadcrumbs, 1/2 cup of shredded cheese, milk, egg, chopped onion, garlic powder, salt, and pepper.

Step 3:

Mix the ingredients until well combined.

Step 4:

Spread the meat mixture evenly into a greased casserole dish.

Step 5:

Top with the remaining shredded cheese and drizzle ketchup over the top.

Step 6:

Bake for 45-50 minutes or until fully cooked through.

Step 7:

Let it cool for a few minutes before serving.

Serving Suggestions Cheesy Meatloaf Casserole

  • Serve with a side of steamed vegetables for a balanced meal.
  • Pair with mashed potatoes or a fresh garden salad.
  • Add some pickles or coleslaw on the side for crunch.
  • Enjoy with a glass of iced tea or lemonade.

Tips for Success Cheesy Meatloaf Casserole

  • Ensure the meatloaf is well-mixed for even cooking.
  • Use lean ground beef for a lighter version if desired.
  • Store leftovers in the fridge for up to three days.
  • Reheat in the oven or microwave for best results.

Variations

Here are a few easy ways to change it up:

  • Substitute ground turkey or chicken for a leaner option.
  • Add chopped bell peppers or mushrooms for extra veggies.
  • Spice it up with diced jalapeños or chili powder for heat.
  • Use dairy-free cheese and milk for a dairy-free option.

Cheesy Meatloaf Casserole

Follow us on Pinterest for more cozy ideas.

Can I make Cheesy Meatloaf Casserole ahead of time?

Yes, you can prepare the casserole in advance and store it in the refrigerator until you’re ready to bake.

What can I substitute for ground beef?

Ground turkey, chicken, or even lentils can be great substitutes for a different flavor or dietary preference.

How should I store leftovers?

Store leftovers in an airtight container in the fridge for up to three days or freeze for longer storage.

Can I add vegetables to the casserole?

Absolutely! Chopped bell peppers, carrots, or spinach make excellent additions for extra nutrition.
Cheesy Meatloaf Casserole baked dish with melted cheese

Cheesy Meatloaf Casserole

A comforting casserole that combines the classic flavors of meatloaf with melted cheese, perfect for busy weeknights.
Prep Time 15 minutes
Cook Time 50 minutes
Total Time 1 hour 5 minutes
Servings: 6 servings
Course: Dinner, Main Course
Cuisine: American
Calories: 400

Ingredients
  

Protein
  • 1 lb ground beef Use lean ground beef for a lighter version if desired.
Rice/Grains
  • 1 cup breadcrumbs
Veggies
  • 1 onion, chopped
Cheese
  • 1 cup shredded cheese
Liquid
  • 1/2 cup milk Use dairy-free milk for a dairy-free option.
Binders
  • 1 ea egg
Sauce
  • 1/2 cup ketchup
Spices
  • 1 tsp garlic powder
  • Salt and pepper to taste

Method
 

Preparation
  1. Preheat the oven to 350°F (175°C).
  2. In a large bowl, combine ground beef, breadcrumbs, 1/2 cup of shredded cheese, milk, egg, chopped onion, garlic powder, salt, and pepper.
  3. Mix the ingredients until well combined.
  4. Spread the meat mixture evenly into a greased casserole dish.
  5. Top with the remaining shredded cheese and drizzle ketchup over the top.
Cooking
  1. Bake for 45-50 minutes or until fully cooked through.
  2. Let it cool for a few minutes before serving.

Notes

Serve with a side of steamed vegetables for a balanced meal. Store leftovers in an airtight container in the fridge for up to three days or freeze for longer storage. You can prepare the casserole in advance and store it in the refrigerator until you’re ready to bake.
Written By

Stephanie Mitchell

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